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The purpose of this study is to investigate how engagement in leisure time activities influences subjective well-being via perceived leisure satisfaction, as well as the moderating role of perceived severity of COVID-19 in these associations. The data for the analysis were collected using a convenience sampling method from 405 people working in various areas of Turkey via an online survey. Regression analysis, mediating effect analysis, and conditional process analysis were used to examine the hypotheses. The mediation analysis result reveals that leisure time satisfaction plays a mediating role in the relationship between leisure time activities' participation level and subjective well-being. The results of the conditional process analysis demonstrate that the perceived severity of COVID-19 has a conditional influence on the direct and indirect relations between the variables in the conceptual model of the research.
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The new coronavirus disease-2019 is clearly showing its effect in our country and around the world. Dizziness or balance disorder is defined as a clinical manifestation of COVID-19 as of 2020. Balance disorders should not be underestimated as they have been shown to be a notable clinical finding in coronavirus disea se-2019patients. Coronavirus disease-2019post-treatment and balance disorders should be thoroughly investigated. Non-specific symptoms, especially vestibular disorders, can be easily overlooked during evaluation. Therefore, this is a situation that requires attention in the clinic. The purpose of this review is to examine the studies in the literature on how the vestibular system is affected in people who are infected by coronavirus disease-2019. © 2022 AVES. All Rights Reserved.
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Background: The 2019 novel coronavirus disease (COVID-19) has caused a global health catastrophe by affecting the human population around the globe. Unfortunately, there is no specific medi-cation or treatment currently available for COVID-19. Objective: It is extremely important to find effective drug treatment in order to put an end to this pandemic period and return to normal daily life. In this context and considering the urgency, rather than focusing on the discovery of novel compounds, it is critical to explore the effects of existing herbal agents with proven antiviral properties on the virus. Methods: Molecular docking studies were carried out employing three different methods, Glide extra precision (XP) docking, induced fit docking (IFD), and molecular mechanics/generalized born surface area (MM/GBSA), to determine the potential antiviral and antibacterial effects of 58 phytochemicals present in Rosmarinus officinalis, Thymbra spicata, Satureja thymbra, and Stachys lavandulifolia plants against the main protease (Mpro) and angiotensin-converting enzyme 2 (ACE2) enzymes. Results: 7 compounds stood out among all the molecules, showing very high binding affinities. Accord-ing to our findings, the substances chlorogenic acid, rosmarinic acid, and rosmanol exhibited extremely significant binding affinities for both Mpro and ACE2 enzymes. Furthermore, carnosic acid and alpha-cadinol showed potent anti-Mpro activity, whereas caffeic acid and carvacrol exhibited promising anti-ACE2 activity. Conclusion: Chlorogenic acid, rosmarinic acid, rosmanol, carnosic acid, alpha-cadinol, caffeic acid, and carvacrol compounds have been shown to be powerful anti-SARS-CoV-2 agents in docking simulations against Mpro and ACE2 enzymes, as well as ADME investigations.
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Purpose: The aim of this article is to shed light on the impact of intangible resources, such as organizational learning (OL), organizational agility (OA) and organizational innovativeness (OI), on supply chain resilience (SCR). For this, a theoretical model is developed to analyze the development of relationships between chosen resource variables. Design/methodology/approach: This study is based on a cross-sectional questionnaire. Survey data were collected from 180 businesses including only medium to senior level managers to ensure a thorough understanding about the company's inner workings and supply chain (SC). The validity of the model is determined using structural equation modeling (SEM) and tested using lavaan package in R. Findings: The findings indicate a statistically significant relationship between OL and SCR. Two organizational resource constructs, OI and OA, are found to have a strong mediating effect on this relationship. OL ability mediated by OA and OI results in increased SCR. Research limitations/implications: The data cover multiple sectors but are collected from one country. The dataset is also limited in that it is collected from mid- to high-level managers working on manufacturing and supply chain-related departments. Practical implications: The authors believe that the results of this study will guide both managers and academics in developing effective measures to avoid SC disruptions due to the Covid-19 pandemic or other comparable risks. Originality/value: This is the first study that examines the relationship between OL and SCR. Prior studies have examined the relationship between OA and SCR. However, OL and OI, in particular, have not featured frequently in SCR-related studies. In this regard, this research is also unique in that it examines the mediating role of OA and OI in the relationship between OL and SCR. © 2022, Emerald Publishing Limited.
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Purpose: This paper aims to clarify the effects of learning culture and trust on supply chain resilience (SCR) and to investigate their role specifically during COVID-19 pandemic to aid decision-makers. For this, a conceptual model proposing relations between variables was developed. The focal point of this research is to investigate the relationship between organizational learning culture (OLC) and SCR, and the mediating effect of supplier trust (ST) in the relationship before and during a pandemic. Design/methodology/approach: This study relies on a unique dataset collected through two separate cross-sectional surveys corresponding to pre- and during-pandemic times that were conducted at the same time. The questionnaire was collected from 245 medium- to senior-level managers, to ensure a thorough understanding about the company’s inner workings and supply chain (SC). To test the proposed research model, the authors processed their data and model using lavaan package in R. Findings: The findings show that OLC and ST have positive and significant effects on SCR. Furthermore, learning culture also triggers ST. Thus, it is ST that explained, as a mediator, the positive effects of OLC on SCR. All these findings are similar for both before and after the pandemic. A critical finding is about the effect of size (small vs. large) and ownership (local vs. multinational). The analysis suggests that during pandemic multinational companies and larger organizations exhibit higher SCR than their counterparts. Research limitations/implications: First, responses to the questionnaire were collected from only one country. Cross-cultural comparisons can be made by collecting data from different countries in future research. Second, the data were obtained from companies operating in different sectors, with a majority in manufacturing. It is possible to obtain more specific findings by analyzing responses from a specific industry. Third, results of this study reflect responses of only SC and manufacturing managers, but other departments such as marketing or finance can also complement the findings. Finally, several other organizational variables may be factored in as moderators to enrich the conceptual model. Practical implications: The authors believe that findings of this research will guide shareholders and managers to develop effective strategies in order to prevent SC disruptions during similar risk/shock scenarios. Originality/value: Similar to earlier research, this study considers the importance of ST on SCR. But this study differs in analyzing the effects of OLC on SCR directly and in taking the mediating effect of ST into account. The authors test the strengths of these relationships individually before and during COVID-19 pandemic. Under pandemic conditions, the authors present empirical evidence on the effects of organizational learning and ST on SCR. In contrast to previous research on SCR, this study connotes the importance of an organization’s internal dynamic capabilities in developing resilience. © 2022, Emerald Publishing Limited.